Direct Observation of Reversible Biomolecule Switching Controlled By Electrical Stimulus

TitleDirect Observation of Reversible Biomolecule Switching Controlled By Electrical Stimulus
Publication TypeJournal Article
Year of Publication2014
AuthorsPranzetti A, Davis M, Yeung CL, Preece JA, Koelsch P, Mendes PM
JournalAdvanced Materials Interfaces
Volume1
Start Page1400026
Pagination1400026
Other Numbers10.1002/admi.201400026
KeywordsElectrochemistry, self-assembled monolayers, sum frequency generation, switchable surfaces
Abstract

In situ sum-frequency-generation spectroscopy is used for the first time to study changes in molecular orientations in charged biofunctionalized self-assembled monolayers, in response to an applied electrical potential. The findings presented here unravel the mechanism by which charged biomolecules control biomolecular interactions, for example, protein binding affinities, and lay the foundation for future studies aiming to explore molecular conformational changes in response to electrical stimuli.