|Title||Direct Observation of Reversible Biomolecule Switching Controlled By Electrical Stimulus|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Pranzetti A, Davis M, Yeung CL, Preece JA, Koelsch P, Mendes PM|
|Journal||Advanced Materials Interfaces|
|Keywords||Electrochemistry, self-assembled monolayers, sum frequency generation, switchable surfaces|
In situ sum-frequency-generation spectroscopy is used for the first time to study changes in molecular orientations in charged biofunctionalized self-assembled monolayers, in response to an applied electrical potential. The findings presented here unravel the mechanism by which charged biomolecules control biomolecular interactions, for example, protein binding affinities, and lay the foundation for future studies aiming to explore molecular conformational changes in response to electrical stimuli.